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Among them, 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP) and its active metabolite 1-methyl-4-phenylpyridinium (MPP+) can ablate dopaminergic and mildly perturb motor ability in various animal species including non-human primates, and also show the highest survival rate of cells after modeling, which is currently recognized as an effective Parkinson's Disease Inducer. At Creative Biolabs, we provide stable and efficient MPP+ induction modeling, cell death assays and other related tests to pave the way for your research.

Creative Biolabs has long-term devoted to the development and application of neuronal models for neuroscience research. Based on our years of research, now we can provide novel human iPSC derived neuronal cell culture modelsÂfor our clients all over the world.

Today, miRNA-based gene regulation is implicated in disease etiology and has been explored for treatment. As a reliable and skillful supplier in the world, Creative Biolabs devotes to the existing knowledge about miRNAs synthesis and is committed to preclinical and clinical trials that have been initiated for miRNA-based therapeutics. Here, we provide one-stop, customized miRNA synthesis services to create high-quality and high-bioactivity oligonucleotides for global scientists.

Creative Biolabs provides oligonucleotide synthesis services via solid-phase synthesis. We hold the commitment to offering unmatched services coupled with a dedication to advancing your programs. When you partner with Creative Biolabs as your trusted supplier, you will maximize your budget and resources with our expertise in designing and synthesizing complex oligonucleotides, including microRNAs (miRNA), small-interfering RNAs (siRNAs), messenger RNA (mRNA), bridged nucleic acid (BNA), and the others.

Creative Biolabs offers the world leading custom TCR development service with the most advanced techniques and years of experiences to establish the solid platform for TCR production. Our technical experts are looking forward to designing a strategy of TCR biomarker identification & selection required for your assays and will be able to recommend an approach appropriate to your project needs.

At Creative Biolabs, we provide a comprehensive range of products and tailored solutions for every stage of CAR-T therapy development, which are designed to streamline workflows and enhance the efficiency of T-cell engineering, helping to overcome technical hurdles and expedite the research. We prioritize close collaboration with academic institutions, biotech companies, and pharmaceutical firms, delivering both technical expertise and ongoing support throughout the development process.

The World Health Organization (WHO) has recently taken a significant step by authorizing the first monkeypox vaccine for children. This development is crucial in the ongoing battle against the virus, particularly as it continues to spread in various regions, including parts of Africa. This authorization is aimed at protecting children, one of the most vulnerable groups, from the debilitating effects of the disease. Monkeypox, caused by the monkeypox virus, is a zoonotic infection that presents with symptoms similar to those of smallpox, including fever, rash, and painful lesions. Children are particularly at risk due to their developing immune systems, making them more susceptible to severe outcomes. The recent outbreaks have underscored the urgent need for a targeted immunization strategy to curb the spread among this demographic.

Introduction Monkeypox, a zoonotic viral infection, has recently garnered significant attention due to its rapid spread and the declaration of a global health emergency by the World Health Organization (WHO). As a biotech researcher, it is crucial to stay abreast of the latest developments in the field to understand the virus better and develop effective diagnostic and therapeutic strategies. Understanding Monkeypox Monkeypox is caused by the monkeypox virus (MPXV), a double-stranded DNA virus that belongs to the Orthopoxvirus genus. The infection is characterized by flu-like symptoms, including fever, muscle aches, and swollen lymph nodes, followed by a distinctive rash that progresses from macules to papules, vesicles, and pustules before crusting over. While the disease is generally milder than smallpox, it can still cause significant discomfort and complications, especially in immunocompromised individuals and children.

Lewis (Le) antigens are fucosylated carbohydrates (oligosaccharides) linked to lipids or proteins and thus present as glycolipids or glycoproteins. As a well-known specialist in antibody fields, Creative Biolabs has paid attention to glycomics research for many years, including Lewis antigens, and has gained high recognition to be a top-ranking service supplier. With assistance by us to understand the pattern of the expression of Lewis antigens in normal tissues, together with the physiological functions, will set the framework to know their altered regulation and tumor-promoting abilities in the cancer context.

Lewis (Le) antigens are fucosylated carbohydrates (oligosaccharides) linked to lipids or proteins and thus present as glycolipids or glycoproteins. As a well-known specialist in antibody fields, Creative Biolabs has paid attention to glycomics research for many years, including Lewis antigens, and has gained high recognition to be a top-ranking service supplier. With assistance by us to understand the pattern of the expression of Lewis antigens in normal tissues, together with the physiological functions, will set the framework to know their altered regulation and tumor-promoting abilities in the cancer context.

Carbohydrate antigens are polysaccharides and glycoconjugates of multiple structural configurations. Although recognition of carbohydrates as antigens starts from microbial polysaccharides, the range of investigation of carbohydrate antigens has been substantially extended. The era of glycomics just begun, and Creative Biolabs as a professional research institute has gained considerable fame in the world and our seasoned scientists already devote to this emerging field for more glycans and carbohydrate antigens details.

As an experienced supplier and a professional institute in antibody markets, Creative Biolabs has gained a high reputation for successfully accomplishing projects around the world. We have one of the largest biologics resource libraries and can provide high-quality and cost-efficient customized glycomics services for further studies of glycolipid structure, synthesis, and function.

Blood group antigens are carbohydrates that attached to lipids or proteins. An antigen is a foreign substance to the body that induces an immune reaction. An immune response occurs when antibodies, proteins in immune systems, are summoned to attack an antigen. Creative Biolabs is known as a world-class institute and professional biotechnique company that has spent a large amount of money and energy in carbohydrate antigens, especially blood group antigens, to further explore their properties, structures, synthesis, and expressions in physical progressions.

Blood group antigens are carbohydrates that attached to lipids or proteins. An antigen is a foreign substance to the body that induces an immune reaction. An immune response occurs when antibodies, proteins in immune systems, are summoned to attack an antigen. Creative Biolabs is known as a world-class institute and professional biotechnique company that has spent a large amount of money and energy in carbohydrate antigens, especially blood group antigens, to further explore their properties, structures, synthesis, and expressions in physical progressions.

Sialic acids are typically found as terminal residues on the glycan chains of vertebrate glycoconjugates and play important roles in protein recognition and immunization activities against exogenous virus. Sialic acids have the potential for more unique and varied biological functions due to their higher structural complexity. Sialic acids binding lectins can be found in many microbes, plants and animals. Studies of these sialic acids recognizing proteins by sialic acids microarrays are rapidly growing. As a leading supplier in the field of microarrays, Creative Biolabs is committed to designing and developing various effective biological microarray products for research. Our microarray test platform provides convenient and rapidly sialic acid binding analyzation with proteins, virus or other microorganism to help our global customers conduct relevant research and reduce research costs.

Sialic acids are typically found as terminal residues on the glycan chains of vertebrate glycoconjugates and play important roles in protein recognition and immunization activities against exogenous virus. Sialic acids have the potential for more unique and varied biological functions due to their higher structural complexity. Sialic acids binding lectins can be found in many microbes, plants and animals. Studies of these sialic acids recognizing proteins by sialic acids microarrays are rapidly growing. As a leading supplier in the field of microarrays, Creative Biolabs is committed to designing and developing various effective biological microarray products for research. Our microarray test platform provides convenient and rapidly sialic acid binding analyzation with proteins, virus or other microorganism to help our global customers conduct relevant research and reduce research costs.

Glycoengineering is increasingly recognized as an important strategy in the development of new biopharmaceuticals with optimized half-life, antigenicity, and efficacy. With years of experience and advanced technologies, Creative Biolabs has proposed different genetic strategies to circumvent issues like heterogeneity, and nonhuman glycans in different glycoprotein production systems. Professional technical experts in Creative Biolabs are dedicated to providing the most comprehensive glycoengineering service and we offer our clients high-quality services in your glycoprotein project to help you achieve milestone success.

Thin Layer Chromatography is a widely used technique in analytical chemistry for separating and identifying compounds within a mixture. This method involves applying a sample onto a thin layer of stationary phase and then allowing a solvent to migrate through it. The resulting separation helps researchers to analyze complex samples effectively.

How to test complement activation? Over the past two decades, highly specific monoclonal antibodies have been generated that recognize only neoepitopes exposed in the activation product, which enables direct capture of complement activation products by ELISA or high-capacity immunosorbents without the interference of the nonactivated component. A number of complement activation products have been tested by this method, including the classical pathway (C1rs-C1 inhibitors, C4d and C4bc), alternative pathways (Ba, Bb, and C3bBЬP), C3 (C3a, iC3b/C3bc, and C3d) and terminal reactions sequence (C5a and sC5b-9).

The total complement activity contributes to a comprehensive understanding of the activation status of the complement system to better define disease occurrence, severity, and response to treatment. Therefore, the total complement activity test has very important clinical value in the diagnosis and subsequent treatment of complement-related diseases. The most common methods of total complement activity testsinclude hemolysis assays, liposome lysis, and enzyme-linked immunosorbent assays (ELISAs).

Why Do complement activation test? complement activation tests are developed to find patients suffering from complement deficiency. Deficiencies in complement components and their regulatory molecules have been reported in a variety of diseases, such as recurrent infections, autoimmune and renal diseases. Today, these tests are also widely used for drug development of new complement-targeted drugs. Therefore, functional or activity tests are of great importance to screen complement defects and complement-targeted drug development.

Creative Biolabs provides a range of ready-to-use aptamers targeting proteins, compounds, bacteria, viruses and cells. You can find ones of interest and the products with high purity and strict QC will be delivered for you. Learn more about aptamer assay protein.

Creative Biolabs provides a range of ready-to-use aptamers targeting proteins, compounds, bacteria, viruses and cells. You can find ones of interest and the products with high purity and strict QC will be delivered for you. Learn more about aptamer assay protein.

Creative Biolabs provides a range of ready-to-use aptamers targeting proteins, compounds, bacteria, viruses and cells. You can find ones of interest and the products with high purity and strict QC will be delivered for you. Learn more about aptamer and protein detection.

The Classic Way in Aptamer The conventional method for aptamer screening, known as systematic evolution of ligands by exponential enrichment (SELEX), rapidly identifies optimal binding sequences from a random population. SELEX involves multiple rounds of selection and amplification cycles. Learn more about Selex aptamer.

In the stem cells therapy, the induced pluripotent stem cells (iPSCs) which are directly derived from patients' somatic cells reprogramming to an embryonic-like state. Since iPSCs could be coaxed into the desired cell types that would already be genetically matched with the patient, the immune rejection and the ethical issues can be potentially circumvented. Learn more about iPSC derived stem cell therapy.

As a biotechnology company specializing in stem cell research, we offer a comprehensive range of services to support the research and development of novel therapies for various diseases. Our disease-specific stem cell therapy development services include: Patient-derived stem cell isolation and characterizationDisease modeling using iPSCsDrug screening and efficacy testingCustomized stem cell-based therapy development Learn more about stem cell research for liver disease.

Creative Biolabs provides key sequencing-based methods used in the analysis of epigenomes, including bisulfite sequencing, chromatin immunoprecipitation sequencing, 3D chromatin capture, as well as the determination of open chromatin. Learn more about stem cell gene sequencing.

Empowered by leading technology and years of experience in biomedical science, Creative Biolabs offers assay development service that includes in vitro and in vivo. As a service provider, our goal is to provide the highest level of service, confidentiality and customer support. Learn more about stem cell viability assay.

Alzheimer's disease (AD), the most common type of dementia, is projected to triple in prevalence by 2050, posing a major worldwide health concern with significant implications for individuals and society. The initial symptoms of AD are insidious, progressive problems centered on episodic memory. The criteria for amnestic-moderate cognitive impairment (MCI) may be met at this point. Memory challenges, loss of confidence, and difficulties multitasking follow. Cognitive impairments become severe and pervasive as the condition progresses, even interfering with regular life tasks. At this time, patients can be diagnosed with Alzheimer's disease dementia. Learn more about Alzheimer's Disease related antibodies

The glucocerebrosidase (GBA) gene mutation is a very important and common risk factor for Parkinson's disease (PD). Some Gaucher disease (GD) patients and GBA mutation carriers are prone to develop PD. In addition, the frequency of PD patients carrying GBA mutations is also greatly increased. In most PD patients, GBA mutations are more common than other PD-related genes. Learn more about GBA antibodies.

TDP-43 (TAR DNA binding protein 43), expressed by the TARDBP gene, can bind both DNA and RNA and plays a critical role in intracellular RNA transcription, alternative splicing, and regulation of mRNA stability. Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) are both defined by lesions caused by aberrant TDP-43 aggregation. TDP-43 is the third protein associated with Alzheimer's disease (AD), and it plays a key role in AD progression. Apart from tau and amyloid-β (Aβ), most AD patients also have TDP-43 accumulation in the limbic regions. This accumulation has been dubbed the limbic predominance of age-related TDP-43 neuropathological changes in encephalopathy (LATE-NC). Learn more about TDP-43 antibodies.

Alpha Synuclein (SNCA, α-Synuclein) is a soluble protein expressed in the presynaptic and perinuclear regions of the central nervous system (CNS). SNCA is one of the earliest genes associated with Parkinson's disease (PD). SNCA is closely linked to the pathogenesis and associated dysfunction of PD and is the major component of Lewy bodies. At the same time, studies have shown that SNCA is involved in the pathological process of Alzheimer's disease (AD). More than 50% of AD patients have been found to have SNCA tangles in their brains, and patients with SNCA tangles tend to show faster cognitive decline than pure AD patients. Learn more about alpha synuclein antibodies.

Neutralizing Antibodies and Antimicrobial Peptides Targeting S Protein Neutralizing antibodies are induced by antigens to protect cells from pathogen infection. Most neutralizing antibodies function at the earliest steps of viral infection through blocking interaction of the virus with cellular receptors and prevent entry into host cells. It has been reported that RBD of S protein efficiently elicits neutralizing antibodies against MERS-CoV by blocking viral entry at the binding step.

Andes Virus (ANDV), a type of orthohantavirus, belongs to the family Hantaviridae which consists of 5 genera: bunyavirus, phlebovirus, nairovirus, tospovirus, and hantavirus. This virus was first found in rodent at Andes mountains of Chile and Argentina. ANDV infection is a leading cause of hantavirus cardiopulmonary syndrome (HCPS), hantavirus pulmonary syndrome (HPS), and hemorrhagic fever with renal syndrome/failure (HFRS). ANDV maintains persistent apathogenic infections in rodents and is easily transmitted to humans mainly through inhalation of aerosolized rodent excreta or rodent bites, leading to the occurrence of ANDV-infected diseases. Besides, ANDV is the only hantavirus that is capable of person-to-person transmission.

LAG-3 inhibitor plays an important role in T cell proliferation and activation as a negative regulator of these processes. Along with other inhibitory receptors, LAG-3 helps to keep cytotoxic CD8+ T cells in an exhausted state during highly inflammatory environments such as a chronic viral infection. LAG-3 has also been implicated in memory T cell expansion, Treg function, and the activation and maturation of dendritic cells.

Normally, checkpoint inhibitors have to be tested for immuno-modulatory activities using functional assays. Following stimulation, execution of functional assays is performed, such as T cell proliferation assay, cytokine production assay, and T cell cytotoxicity assay. These functional assays are offered in a high throughput method so multiple molecules and conditions can be incorporated. Tailored immune checkpoint assay is also available. In that case, a unique reporter cell line could also be used to determine if your inhibitor can restore immune cell function.

With our world-leading technology platforms and professional experts at antibody development, Creative Biolabs has perfected our technical pipelines in immune checkpoint antibody development. Our comprehensive service portfolio includes polyclonal antibody discovery and development, monoclonal antibody (mAb) discovery and development, antibody fragment discovery and development, antibody characterization, antibody engineering and optimization, antibody production, and manufacture. We will share our knowledge and passion for immune checkpoint antibody development to facilitate our customers' research and project development.

Numerous cell lines, including Vero and HeLa cells, can isolate orthopox viruses. The method of identification has been subcultured to chick chorioallantoic membrane cells, although more recent techniques, including NAA, are being employed more and more for end-point assessment. Creative Biolabs has been keeping a close eye on the development of the epidemic situation. The cell culture scientists at Creative Biolabs are focused on optimizing all characteristics unique to your cell lines in order to manufacture cell lines effectively and in accordance with your specifications. Learn more about monkeypox cell lines.

With years of experience, Creative Biolabs can offer an extensive range of recombinant proteins and peptides including orthopoxviruses family, parapoxviruses family, molluscipoxviruses family, yatapoxviruses family, capripoxviruses family, suipoxviruses family, leporipoxviruses family and avipoxviruses family. Creative Biolabs is committed to providing highly customized comprehensive solutions with the best quality to advance your projects. Learn more about monkeypox peptides.

With years of experience, Creative Biolabs developed a comprehensive list of Monkeypox related products to support the development of antibody and other therapeutics, including recombinant proteins and peptides, antibodies, plasmids, PCR primers and probes, cell lines, inhibitors, virus like particles and pseudoviruses and detection kits.

What Can We Do About In Vivo Neuroscience ServiceAfter years of accumulation, Creative Biolabs has established an advanced experimental platform and a professional scientist team., which aims to provide global clients with high-quality in vivo neurological services using the most suitable animal models. In addition to different kinds of animal models, other in vivo sampling and testing services are also available within our scope

In Vivo ALS Diverse animal modelsCreative Biolabs offers a range of animal models for the research of different diseases, such as AD, PD, Amyotrophic Lateral Sclerosis (ALS), and Frontotemporal Lobar Degeneration (FTLD), etc.Rigorous experimental processAll experiments were performed in vivo, on freely moving rodent models of different diseases.Comprehensive experimental analysisWe offer in vivo tissue collection, behavioral testing, and tissue sampling. To maximize information for each tissue sample, we also perform analyses of biological fluids and tissues.Customized serviceTo meet the specific needs of your research or drug discovery project, we also provide customized in vivo models and tests.

Neural Circuit Mapping In the study of the central nervous system, viral vectors are used not only to analyze the function of neural circuits, but also to study diseases or as gene therapy vectors due to their unique gene delivery characteristics and target specificity. Adeno-associated virus (rAAV) vectors and lentivirus (LV) vectors are currently the most used vectors in central nervous system research and gene therapy clinical trials in rodents and primates.

Neuron Illustration Neuroimaging plays a critical role in psychiatry as it can potentially be used to identify biomarkers of disease, prognosis, or treatment, elucidate biological pathways, and help redefine diagnostic boundaries and inform and monitor new therapies. The insight into the neural mechanisms of psychiatric symptoms achieved through neuroimaging has already informed new nonpharmacological interventions. Imaging biomarkers have been relatively successful in the field of neurodegenerative disorders. Imaging biomarkers have also been used for proof-of-concept in the evaluation of new interventions for dementia.

Neural Progenitor Cells Derived from early blastocyst embryos, human embryonic stem cells (hESC) are self-renewable cells with pluripotency. Under special culture conditions, neural cells can be generated from hESC including glial cells, functional neurons, and oligodendrocytes. To avoid other lineage cells as contaminants, the neural progenitor (NP) cell population is necessary to the neural lineage and has been served as an unlimited lineage-restricted cell source for therapeutic and research.

Dopaminergic Neurons Differentiation During years of exploration in neural differentiation models, Creative Biolabs has developed a comprehensive technology platform with a variety of available models. Our platform is now equipped with advanced facilities, experienced experts, and the latest technologies. With these strong foundations, we are confident in offering custom dopaminergic neurons differentiation model services to global clients.

Ion Channels In Neurons Ion channels regulate crucial electrical functions throughout the body, including the heartbeat, sensory transduction, and CNS function. Given the central role in many physiological processes, they represent an attractive target class for drug discovery. They are enormous potential for the intervention of disease states in various disorders, particularly in the CNS and cardiovascular systems. The recognized importance of ion channel proteins in health and disease has led to an active search for ion channel targets and novel therapeutics in the worldwide drug discovery market.

Description of Neural Circuits The basic connection types between neurons are chemical synapses and electrical synapses. The synaptic connections always consist of dendrites, axons terminals, and glial cells, which together constitute neuropil. In this case, the neuropil between nerve cell bodies is the area where the most synaptic connections occur.

Creative Biolabs aims to provide the best and most practical complement-related services based on a reliable and standardized complement assay platform. We offer customized complement factor P functional tests for the quick evaluation of complement activity.

The complement factor P functional test is a laboratory test used to assess the activity and functionality of the complement component factor P in the blood, which can be performed by hemolytic assay and enzyme-linked immunosorbent assay (ELISA).

With the latest state-of-the-art technology and extensive experience, Creative Biolabs is the reliable choice for complement genetic testing, providing the highest standards in genetic testing with the latest technology, strictest quality control, and unprecedented service and reliability.

Creative Biolabs is one of the well-recognized expert professionals in the field of complement therapeutics and related services. Our technical experts are looking forward to offering high-quality and custom complement inhibitor validation services for our clients.

Bioprinting organs iPSC for 3D bio-printing is also widely used to detect drugs. By printing organs on the chip, it can better simulate the internal environment of the human body, thereby improving the accuracy and efficiency of drug detection. The figure below shows a system that integrates the heart, lungs, and liver. Compared with traditional drug detection methods, this can be done in the laboratory at a lower cost and better simulate the living environment. This technology proves that accurate models can improve the way we evaluate new drugs, such as generating "organoids" composed of multiple types of cells, and tumor models with engineered blood vessels.

iPSC-derived Cell Therapy Development In the stem cells therapy, the induced pluripotent stem cells (iPSCs) which are directly derived from patients' somatic cells reprogramming to an embryonic-like state. Since iPSCs could be coaxed into the desired cell types that would already be genetically matched with the patient, the immune rejection and the ethical issues can be potentially circumvented.

CAR with Half of CTLA-4Recently, some researchers have combined CCT with CAR-C-terminal to construct three CARs targeting CD22: CAR-1CCT, CAR-2CCT, and CAR-3CCT, which also improved tumor therapeutic efficacy after gaining endocytosis.

IL4I1 in Autoimmunity and Cancer The link between IL4I1 and various autoimmune diseases, specifically those involving T cell autoimmunity, could be attributed to the suppressive effect IL4I1 exerts on T cell responses. Moreover, up-regulated IL4I1 in inflamed tissues creates an immunosuppressive local environment that hinders an effective immune response.The same immune suppressive characteristics of IL4I1 play an entirely different role in cancer. IL4I1 is highly expressed in many human cancers, including breast, ovarian, gastric, and melanoma, among others. The immunosuppressive metabolites of IL4I1 catalytic activity, specifically H2O2, aids in local immune escape, promoting tumor growth and progression. It also contributes to the protumorigenic pattern of immune cells in the tumor microenvironment, simultaneously inhibiting anti-tumor immune responses.

Interleukin 18 binding protein (IL-18BP) is a protein that plays a role in the immune system. It is involved in the regulation of interleukin 18 (IL-18) activity, which contributes to the fine-tuning of the immune system and helps maintain immune homeostasis. IL-18 is produced by a variety of cell types, including macrophages, dendritic cells, and epithelial cells, and is involved in the regulation of innate and adaptive immune responses. IL-18 acts by binding to its receptor complex, which consists of IL-18Rα and IL-18Rβ, thereby activating downstream signaling pathways.

The concept of IL-18BP as a secreted immune checkpoint has been explored in scientific studies. It has the potential to serve as a target for therapeutic intervention in situations where modulation of the immune response is required. Creative Biolabs explores the biological properties of IL-18BP and its significance in immune regulation.

What Are Gamma Delta T Cells? γδ T cells are a population of innate-like T lymphocytes characterized by T-cell receptors (TCRs) composed of γ and δ chains. They are widely distributed in the peripheral blood (PB) and mucosal tissues. γδ T cells have been revealed to exert dual roles in tumor immunity. On the one hand, γδ T cells suppress tumor occurrence by multiple mechanisms, including cytotoxicity against infected or tumor cells, cytokine and chemokine production, antigen-presenting functions, and regulatory abilities. On the other hand, γδ T cells exert suppressive effects on antitumor responses.

Creative Biolabs is supported by an advisory board with seasoned professionals in γδ T cell receptors (γδ TCR) studies, γδ T cell immunologic analysis, as well as γδ T cell therapy development. We have accumulated extensive experience from the accomplishment of different projects, during which we have received a lot of recognition and praise from our clients.

TCR Repertoire Sequencing Creative Biolabs has an entrepreneurial team of highly-skilled and qualified experts in γδ TCR studies and γδ T cell therapy development. The members have originated from a rich academic research background, bringing their experience into translation. We are very proud of providing high-quality, omnidirectional γδ TCR services to our valued clients to remove the difficulties of your projects.

Vδ1 is paired with various Vγ chains such as Vγ2, Vγ3, Vγ4, Vγ5, Vγ8, and Vγ10, to form different γδ T cell subsets. Vδ1+ γδ T cells play an anti-tumor effect in multiple cancers, such as chronic lymphoid leukemia, breast cancer, and multiple myeloma.

With years of experience, scientists at Creative Biolabs have developed a series of viral vectors for neuroscience research. We are therefore confident in offering the best products and services for our clients all over the world.

Creative Biolabs is at the forefront of scientific innovation, continuously striving to develop groundbreaking technologies that advance the field of neuroscience. Our latest cutting-edge service, the Brain Liquid Biopsy Assay, has revolutionized the field of neurological diagnostics. By harnessing the power of circulating tumor cells (CTCs) analysis, brain-derived exosomes analysis, and cfDNA analysis, our Brain Liquid Biopsy Assay service offers unparalleled insights into the complex workings of the brain and opens new avenues for diagnosis, monitoring, and treatment of neurological disorders.

The versatility and precision of Creative Biolabs' Brain Imaging Platform make it applicable to a wide range of research areas in neuroscience. Some notable applications include: Brain Tissue Imaging Mouse brains, tree shrew brains, marmoset brains, macaque brains.AI Pathological Analysis High-precision and fast fluorescence imaging analysis of internal structures in pathological slices related to neurological disorders.Neural Circuit Analysis Fast analysis of tracing virus for rapid analysis of behavior-related neural circuits.Neural Gene Profiling Suitable for analyzing the expression of immediate-early genes in brain tissue.

Creative Biolabs offers a cutting-edge suite of advanced neural cell assays that revolutionize the landscape of neuroscience research. Creative Biolabs offers a diverse range of cell types, ranging from primary neuronal cultures to cell lines derived from neural tissue. These resources are employed to enhance the investigation of cellular processes under controlled conditions, ultimately leading to a deeper comprehension of the nervous system's structure and operation.

At Creative Biolabs, we enhance your research and data relevancy by acquiring and reprogramming induced pluripotent stem cells (iPSC) from a specific patient's clinical profile. We have developed streamed-line protocols for efficient iPSC generation with viral vectors, DNA (plasmid), RNA, and recombinant proteins. Creative Biolabs also provides IPSC maintenance services and large-scale pluripotent cell production in both 2D and 3D formats. In addition, pluripotent characterization assays and custom genome editing services in human cells, including cell lines and patient-derived cells are also available.

Creative Biolabs is dedicated to providing several viable and cost-effective methods for pluripotent stem cells (iPSC) reprogramming. We employ advanced iPSC reprogramming factor delivery strategy by virus, iPSC reprogramming factor delivery by episomal vectors, as well as other iPSC reprogramming methods (mRNA, protein) to help you obtaining the desired iPSC.

Nowadays, the application of custom-engineered sequence-specific nucleases enables genetic changes in human cells to be easily made with much greater efficiency and precision, such as CRISPR/Cas9, and TALEN. Engineered double-stranded DNA breaks are able to efficiently disrupt genes, also which can be realized by the right donor vector, engineer point mutations, as well as gene insertions. Nevertheless, in order to ensure the maximum gene targeting efficiency and specificity, a great variety of design considerations should be taken into account. It is especially important when engineering induced pluripotent stem cells (iPSCs), because they are more difficult to transfect and less resilient to DNA damage than immortalized tumor cell lines. With years of exploration in iPSC development, Creative Biolabs is dedicated to providing a full range of iPSC genome editing services for customers all over the world.

Creative Biolabs is supported by an advisory board with seasoned professionals in gamma delta T cell receptors (γδ TCR) studies, γδ T cell immunologic analysis, as well as γδ T cell therapy development. We have accumulated extensive experience from the accomplishment of different projects, during which we have received a lot of recognition and praise from our clients.

Creative Biolabs is a world-leading service provider that focuses on the research of γδ T cells. With highly skilled and committed experts and state-of-the-art technologies, we are fully confident in offering the best γδ T cell isolation services to support the research of γδ T cell biology and the development of γδ T cell-based immunotherapies.

Gamma delta (γδ) T cells have shown promising treatment for infectious diseases and certain types of cancers. As one of the top CRO companies in the field of γδ T cell therapy development for disease therapy, Creative Biolabs has focused on γδ T cell engineering services for years and has accomplished numerous challenging projects in this field. Equipped with deep knowledge and experience in γδ T cell design, we can offer high-quality custom γδ T cell solutions for our valued clients.

Creative Biolabs has rich experience in the research of γδ T cells. We can provide comprehensive γδ T cells services. In order to better understand the potential function of γδ T cells, we also provide γδ T cells functional characterization service as follows.

Experienced in protein chemistry and with a dedicated commitment to the scientific community, Creative Biolabs has perfected our technical pipelines for custom immune checkpoint protein labeling. Our custom immune checkpoint protein labeling service combines years of conjugation expertise with a wide selection of labels, including biotin and fluorescent dyes, along with a choice of labeling chemistries, such as amine labeling, thiol labeling, and other labeling methods.

Normally, checkpoint inhibitors have to be tested for immuno-modulatory activities using functional assays. Following stimulation, execution of functional assays is performed, such as T cell proliferation assay, cytokine production assay, and T cell cytotoxicity assay. These functional assays are offered in a high throughput method so multiple molecules and conditions can be incorporated. Tailored immune checkpoint functional assay is also available. In that case, a unique reporter cell line could also be used to determine if your inhibitor can restore immune cell function.

The immune inhibitory checkpoints play essential roles in mediating immune tolerance and protecting tissues from collateral damage. Two important immune checkpoint receptors, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein 1 and its ligand (PD-1 / PD-L1), have been widely studied in clinical cancer immunotherapy. In addition to checkpoints that suppress T-cell responses, the antiphagocytic signal CD47 has emerged as a key stimulatory checkpoint of innate immunity in clinics. Creative Biolabs combines the most extended range of services and the best experts for immune checkpoint antibody development and will put the necessary resources and solutions to deliver the perfect immune checkpoint antibody humanization services.

With our world-leading technology platforms and professional experts at antibody development, Creative Biolabs has perfected our technical pipelines in immune checkpoint antibody development. Our comprehensive service portfolio includes polyclonal antibody discovery and development, monoclonal antibody (mAb) discovery and development, antibody fragment discovery and development, antibody characterization, antibody engineering and optimization, antibody production, and manufacture. We will share our knowledge and passion for immune checkpoint antibody development to facilitate our customers' research and project development.

Reprogramming macrophages has emerged as a significant approach for treating a variety of diseases. Identification of targets for macrophage reprogramming has receoved more and more attention. Creative Biolabs provides the most comprehensive transcriptional analysis to identify targets for macrophage reprogramming. Our scientific team has the necessary expertise and capabilities to provide overall solutions for the identification of targets for macrophage reprogramming, focusing on innovative research.

Macrophages play an important role in cancer development and metastasis. Proinflammatory M1 macrophages can target cancerous cells, and therefore, can be engineered as drug carriers for tumor therapy. As a leading specialist in engineering macrophages, Creative Biolabs provides comprehensive R&D services of engineering M1 macrophages, macrophage-derived exosomes, and macrophage membrane as drug carriers.

As a leading service provider in the field of antibody discovery and immunotherapy development, Creative Biolabs now presents one-stop development services for CAR-T therapy, which has become a more promising approach among cancer therapies. We offer macrophage polarization assay used to improve the antitumor immunity via promoting inflammation during the one-stop service for further downstream research.

Macrophages are able to initiate a particular type of inflammatory response via the release of a certain pattern of cytokines. They play a major role as immunoregulatory cells. Creative Biolabs has built a highly experienced team of scientists and quality staff that have a long history in macrophage isolation and culture. Human monocytes, human alveolar, murine peritoneal cavity, murine bone marrow, murine lung, and murine adipose tissues are available for macrophage isolation and culture. Our seasoned scientists are pleased to share our expertise and experience with our global clients and facilitate their meaningful macrophage project development.

Creative Biolabs has long-term devoted to the development and application of monoclonal antibodies for neuroscience research. Equipped with world-leading technology platforms and professional scientific staff, our team of experts can assist you in designing the best study outline customized to meet the requirements of your antibody discovery/development program.

Some focus on the use of laboratory animals to mimic genetic defects in humans, while others identify biomarkers to track disease progression. As a leader in the field of biological sciences, Creative Biolabs is committed to providing our clients around the world with the most convenient and accurate biomarker analysis. Years of experience have rewarded us with knowledge and technology proven to be essential for precise biomarker assay.

Creative Biolabs is at the forefront of scientific innovation, offering cutting-edge solutions in the field of neuroscience. With over 20 years of expertise, our team of highly skilled biological specialists has been instrumental in advancing the development and utilization of animal models for studying neurological disorders.

Neurons are the basic components of the central and peripheral nervous systems. They play an important role in transmitting information between different areas of the brain, and between the brain and the rest of the nervous system. There are three types of neurons, sensory neurons, motor neurons, and interneurons. It is estimated that the human brain consists of ~100 billion neurons. Each distinct neuron type expresses a unique set of markers, thus enabling researchers to effectively identify and characterize neuronal cells of interest. Antibodies targeting these neuronal markers are essential tools for scientists engaged in neuroscience research, which may result in a better understanding of many neuroscience processes and neuronal diseases. Antibodies can be applied for characterization, isolation, and localization of target proteins, which are the main techniques in molecular and cellular neuroscience.