What Are Gamma Delta T Cells

What Are Gamma Delta T Cells?

γδ T cells are a population of innate-like T lymphocytes characterized by T-cell receptors (TCRs) composed of γ and δ chains. They are widely distributed in the peripheral blood (PB) and mucosal tissues. γδ T cells have been revealed to exert dual roles in tumor immunity. On the one hand, γδ T cells suppress tumor occurrence by multiple mechanisms, including cytotoxicity against infected or tumor cells, cytokine and chemokine production, antigen-presenting functions, and regulatory abilities. On the other hand, γδ T cells exert suppressive effects on antitumor responses.