TAR DNA Binding Protein 43

TDP-43 (TAR DNA binding protein 43), expressed by the TARDBP gene, can bind both DNA and RNA and plays a critical role in intracellular RNA transcription, alternative splicing, and regulation of mRNA stability. Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) are both defined by lesions caused by aberrant TDP-43 aggregation. TDP-43 is the third protein associated with Alzheimer's disease (AD), and it plays a key role in AD progression. Apart from tau and amyloid-β (Aβ), most AD patients also have TDP-43 accumulation in the limbic regions. This accumulation has been dubbed the limbic predominance of age-related TDP-43 neuropathological changes in encephalopathy (LATE-NC). Learn more about TDP-43 antibodies.