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Vδ1 is paired with various Vγ chains such as Vγ2, Vγ3, Vγ4, Vγ5, Vγ8, and Vγ10, to form different γδ T cell subsets. Vδ1+ γδ T cells play an anti-tumor effect in multiple cancers, such as chronic lymphoid leukemia, breast cancer, and multiple myeloma.