Immune Checkpoint Antibody Humanization

The immune inhibitory checkpoints play essential roles in mediating immune tolerance and protecting tissues from collateral damage. Two important immune checkpoint receptors, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein 1 and its ligand (PD-1 / PD-L1), have been widely studied in clinical cancer immunotherapy. In addition to checkpoints that suppress T-cell responses, the antiphagocytic signal CD47 has emerged as a key stimulatory checkpoint of innate immunity in clinics. Creative Biolabs combines the most extended range of services and the best experts for immune checkpoint antibody development and will put the necessary resources and solutions to deliver the perfect immune checkpoint antibody humanization services.