IL4I1 In Autoimmunity And Cancer

IL4I1 in Autoimmunity and Cancer

The link between IL4I1 and various autoimmune diseases, specifically those involving T cell autoimmunity, could be attributed to the suppressive effect IL4I1 exerts on T cell responses. Moreover, up-regulated IL4I1 in inflamed tissues creates an immunosuppressive local environment that hinders an effective immune response.
The same immune suppressive characteristics of IL4I1 play an entirely different role in cancer. IL4I1 is highly expressed in many human cancers, including breast, ovarian, gastric, and melanoma, among others. The immunosuppressive metabolites of IL4I1 catalytic activity, specifically H2O2, aids in local immune escape, promoting tumor growth and progression. It also contributes to the protumorigenic pattern of immune cells in the tumor microenvironment, simultaneously inhibiting anti-tumor immune responses.